The three key artists of the High Renaissance are Leonardo da Vinci, Michelangelo, and Raphael.

Leonardo Da Vinci: He was an Italian polymath of the High Renaissance. He was also a painter, draughtsman, engineer, scientist, theorist, sculptor, and architect. His greatest masterpiece is the Mona Lisa.

Michelangelo: He was of the High Renaissance. He was also an Italian sculptor, painter, architect and poet. His greatest masterpiece is The Statue of David.

Raphael: He was from the High Renaissance. He was an Italian painter and architect. His greatest masterpiece was The School of Athens.